Retina Created From Stem Cell

In another world first in the fight against degenerative eye disorders, scientists from the Universtiy of California, Irvine, have created an eight-layer early-stage retina from human embryonic stem cells. Not only is this the world's first three-dimensional complex tissue structure to be made from stem cells, but it also marks the first step toward the development of transplant-ready retinas to treat eye disorders affecting millions.

The retina is the part of the eye that records images and sends them from the eye to the brain via the optic nerve. Building on a process designed in a previous study, researchers created multiple cell types using microscopic gradients for solutions in which to bathe the stem cells and initiate specific differentiation paths.

"Creating this complex tissue is a first for the stem cell field," said Hans Keirstead, study leader of the Reeve-Irvine Research Center and the Sue & Bill Gross Stem Cell Research Center at UCI. "Dr. Gabriel Nistor in our group addressed a really interesting scientific problem with an engineering solution, showing that gradients of solutions can create complex stem cell-based tissues. We made a complex structure consisting of many cell types. This is a major advance in our quest to treat retinal disease. What’s so exciting with our discovery is that creating transplantable retinas from stem cells could help millions of people, and we are well on the way.”

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